Factor VIII (FVIII) treatment has more than
50 years of use and over 175 clinical studies.1,2
Count on factor VIII (FVIII) prophylaxis to be there.
Your patients are unique-so they
deserve an individualized treatment.
Establishing a routine with
Factor VIII (FVIII) may
empower patients.
Tailor FVIII Prophylaxis to Fit Their Lives
Management of hemophilia A has evolved beyond a “one-size-fits-all” approach to one that is multidimensional and aligned with each specific patient’s goals and lifestyle.1,2
Some patient characteristics that play into the individualization of FVIII prophylaxis include:
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Age & Weight
Pharmacokinetic (PK) response
Treatment goals
Physical activity & lifestyle
Bleeding phenotype
Adherence to treatment regimen
The patients weight and age determines the dose of FVIII treatment.1,2
Understanding each patient's peak and trough levels, determined by pharmacokinetic analysis, can help in tailoring that patient's dosing regimen around their lifestyle and activities.1
Your patients' goals—from feeling comfortable attending college to slowing joint damage—can inform their prophylaxis regimen.1
Understanding a patient's physical activity and lifestyle can help determine an appropriate dosing schedule to help achieve adequate coverage.1
Bleeding pattern and arthropathy can vary significantly among patients with FVIII levels lower than 1%, including those with identical mutations in the F8 gene.1
It's important to work with your patient to develop a treatment plan that meets their individual needs. Some of the common obstacles to full adherence include denial, lack of patient/parent/family commitment, and the time-consuming nature of prophylaxis. On the other hand, encouraging patients to establish a routine can improve adherence.1
GET THE MOST OUT OF THEIR INDIVIDUAL ROUTINE
The measurability of FVIII can help optimize a patient’s treatment regimen by allowing it to be tailored to the parameters of patients’ individual PK curves.1,3
Maintaining optimal factor coverage levels is important during situations with higher bleeding risk. Physical activity (≥50% factor levels), surgery (50%–80%), and trauma/high-risk surgery (>80%) all require level adjustment to reduce the risk of bleeds.3,4
PK-GUIDED PROPHYLAXIS UNIQUE TO YOUR PATIENTS
Using PK-guided prophylaxis with FVIII can help you gain deeper insight into peak and trough levels to better target bleeding patterns. Many patients may respond to a PK-guided routine because their chosen lifestyle and activities play a role in their treatment.5
But remember: this type of treatment requires strong commitment from your patients, as it means more intense monitoring, plus the flexibility to change as their lifestyle does.5
References:
1. Valentino LA. Considerations in individualizing prophylaxis in patients with haemophilia A. Haemophilia. 2014;20(5):607-615. 2. Petrini P, Valentino LA, Gringeri A, Re WM, Ewenstein B. Individualizing prophylaxis in hemophilia: a review. Expert Rev Hematol. 2015;8(2):237-246. 3. Iorio A, Iserman E, Blanchette V, et al. Target plasma factor levels for personalized treatment in haemophilia: a Delphi consensus statement. Haemophilia. 2017;23(3):e170-e179. 4. Broderick CR, Herbert RD, Latimer J, et al. Association between physical activity and risk of bleeding in children with hemophilia. JAMA. 2012;308(14):1452-1459 5. Hazendonk HC, van Moort I, Mathôt RA, et al. Setting the stage for individualized therapy in hemophilia: what role can pharmacokinetics play? Blood Rev. 2018;32(4):265-271.