Factor VIII (FVIII) treatment has more than
50 years of use and over 175 clinical studies.1,2
Count on factor VIII (FVIII) prophylaxis to be there.
Your patients are unique-so they
deserve an individualized treatment.
Establishing a routine with
Factor VIII (FVIII) may
empower patients.
PROPHYLAXIS ROUTINE WITH FVIII
We all have our routines. They help us structure our day and help achieve our goals. And for people with hemophilia A, FVIII routine prophylaxis can help reduce joint bleeds which reduces the risk of joint damage.1
The U.S. Joint Outcomes Study Looked at the impact of FVIII routine prophylaxis
A randomized, multicenter, open-label trial was conducted on 65 boys with severe hemophilia A assigned to prophylaxis (n=32) or enhanced episodic therapy (n=33). Children in the prophylaxis group received FVIII infusions of 25 IU/kg of body weight every other day to prevent bleeding. Children assigned to receive episodic therapy were treated only at the time of clinically recognized joint hemorrhage. Eligible participants were aged less than 30 months at the time of study. The primary endpoint was preservation of index-joint structure, as determined by means of MRI and plain-film radiography.1
SERIOUS ADVERSE EVENTS1*
*Plus-minus values are means SD. CVAD denotes central-venous-access device.
A consistent FVIII prophylaxis routine can reduce the risk of joint damage and decrease the frequency of joint and other hemorrhages when compared with on-demand treatment.1
The US Joint Outcomes Study demonstrates the efficacy of FVIII prophylaxis routines in reducing the incidence of joint hemorrhages and in lowering the risk of joint damage (as assessed by MRI) among young boys with severe hemophilia A.1
†P=0.002.
‡P<0.001.
Joint damage was also assessed by radiography and these results were not statistically significant. The authors concluded that MRI is a preferable imaging technique for young boys with hemophilia A.
Evidence that even a few joint bleeds can lead to joint damage1§
§Some joints with no bleeds had high MRI scores, whereas some joints with more than 10 bleeds did not show bone or cartilage damage on MRI.
¶MRI score is the average of 2 concordant readings; a score of zero indicates a normal joint, and a score of 7–10 indicates damage to joints or cartilage.
"I feel more self-assured and able to plan out my life better, now that I've developed a FVIII routine with my care team."
- James, patient with hemophilia A
Reference:
1. Manco-Johnson MJ, Abshire TC, Shapiro AD, et al. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med. 2007;357(6):535-544.